氨苄西林钠盐 [氨苄青霉素钠盐]，Ampicillin sodium salt；BioXtra, suitable for cell culture

别名：氨苄西林钠；氨苄青霉素钠；D-(−)-α-氨基苄青霉素钠盐；D-(−)-α-Aminobenzylpenicillin sodium salt

Empirical Formula (Hill Notation): C16H18N3NaO4S CAS号: 69-52-3 分子量: 371.39 Beilstein: 4119211 EC 号: 200-708-1 MDL编号: MFCD00064313 PubChem化学物质编号: 24891335 NACRES: NA.76

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: A8351

CAS号: 69-52-3

MDL号: MFCD00064313

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录规格.SKU-Variant

5g
25g
100g

说明

氨苄西林是青霉素的半合成衍生物，具有广谱抗生素的功能。它已用于研究抗生素耐药性和渗透限制、多种抗生素之间的协同作用、某些血流感染，并已用于开发PCR检测，以检测脑脊液中的耐药基因。

一般描述

Chemical structure: ß-lactam

应用

Ampicillin is a semi-synthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.

生化/生理作用

作用方式：该ß-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。
耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。

注意

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.

制备说明

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

其他说明

Keep container tightly closed in a dry and well-ventilated place, hygroscopic.

属性

产品线

BioXtra

质量水平

200

形式

powder

technique(s)

cell culture | mammalian: suitable

杂质

endotoxin, tested

颜色

white to yellow

mp

215 °C (dec.) (lit.)

溶解性

water: soluble 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

安全信息

象形图

GHS08

警示用语：

Danger

危险声明

H317 - H334

预防措施声明

P261 - P280 - P342 + P311

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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