格尔德霉素，Geldanamycin from Streptomyces hygroscopicus；≥98% (HPLC), powder

图片 格尔德霉素，Geldanamycin from Streptomyces hygroscopicus；≥98% (HPLC), powder
格尔德菌素；NSC 122750； Empirical Formula (Hill Notation): C29H40N2O9 CAS号: 30562-34-6 分子量: 560.64 MDL编号: MFCD00274570 PubChem化学物质编号: 329799914 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: G3381
CAS号: 30562-34-6
MDL号: MFCD00274570
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¥4,650.00

说明

一般描述

Chemical structure: benzenoid
 

生化/生理作用

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 
 

属性

sterility

non-sterile

质量水平

300

测定

≥98% (HPLC)

形式

powder

颜色

yellow to orange

溶解性

DMSO: soluble

抗生素抗菌谱

neoplastics

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES string

CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O

InChI

1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

InChI key

QTQAWLPCGQOSGP-KSRBKZBZSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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