杆菌肽，Bacitracin；from Bacillus licheniformis, ≥65,000 IU/g

图片 杆菌肽，Bacitracin；from Bacillus licheniformis, ≥65,000 IU/g
别名：杆菌肽A；杆菌肽来源于地衣芽孢杆菌；Altracin；Bacitracin A； Empirical Formula (Hill Notation): C66H103N17O16S CAS号: 1405-87-4 分子量: 1422.69 EC 号: 215-786-2 MDL编号: MFCD00062640 PubChem化学物质编号: 57646949 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 11702
CAS号: 1405-87-4
MDL号: MFCD00062640
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说明

一般描述

Chemical structure: peptide
 

应用

Bacitracin is used to study disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is also used to study the biosynthesis of sterols and squalene.
Bacitracin has been used:
  • as a protease inhibitor[1]
  • as a control antibiotic[2]
  • for the calibration in size exclusion chromatography[3]

生化/生理作用

Bacitracin has been shown to decrease vancomycin-resistant Enterococcus faecium population in intestine.[4]
Peptide antibiotic.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.
 
 

属性

生物来源

Bacillus licheniformis

质量水平

200

形式

powder

specific activity

≥65,000 IU/g

颜色

white to pale buff

抗生素抗菌谱

Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES string

[H]N1[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(N)C(C)CC)[C@@H](C)CC)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](Cc4ccccc4)C1=O

InChI

1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1

InChI key

CLKOFPXJLQSYAH-RNHDWVCBSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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