| Chemical Name | Olaparib |
| Synonyms | 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD 2281; KU 0059436; KU 59436; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine; |
| CAS Number | 763113-22-0 |
| Molecular Formula | C₂₄H₂₃FN₄O₃ |
| Appearance | White to Off-White Solid |
| Melting Point | 207-210°C |
| Molecular Weight | 434.46 |
| Storage | Refrigerator |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| Category | Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor. |
| | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| References | Weston, V.J. et al.: Blood, 116, 4578 (2010); Senra, J.M. et al.: Mol. Cancer Therap., 10, 1949 (2011); Schaefer, N.G. et al.: Nuc. Med. Comm., 32, 1046 (2011); |
