头孢噻肟钠盐 [噻孢霉素]，Cefotaxime sodium salt；≥97% (HPLC), suitable for cell culture, Calbiochem®

别名：头孢霉素；头孢赛肟钠盐；头孢噻吩钠盐；Cefotaxim sodium salt；7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7²-(Z)-(O-methyloxime) Acetate, Na, Cefotaxim sodium salt

Empirical Formula (Hill Notation): C16H16N5NaO7S2 CAS号: 64485-93-4 分子量: 477.45 Beilstein: 5711411 MDL编号: MFCD00079073

制造商品牌: 密理博 Millipore , 默克 Merck , 西格玛 Sigma-Aldrich

货号（SKU）: 219504

CAS号: 64485-93-4

MDL号: MFCD00079073

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

头孢菌素类强效β-内酰胺酶耐药抗生素。对革兰氏阳性和革兰氏阴性生物（包括革兰氏阴性厌氧菌）具有活性。抑制细胞壁合成。
头孢噻肟通过与青霉素结合蛋白（PBP）结合来抑制细菌细胞壁合成，所述青霉素结合蛋白抑制细菌细胞壁中肽聚糖合成的最终转肽步骤。结果，由于细胞壁自溶酶，细菌裂解。

一般描述

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis.

生化/生理作用

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Primary Target
Gram-positive

Secondary Target
Gram-negative

其他说明

Broad spectrum third generation cephalosporin antibiotic.

Molinari, G., et al. 1991. J. Chemotherap.3, 6.
Vallee, F., and LeBel, M. 1991. Antimicrob. Agents Chemother.35, 2057.

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

manufacturer/tradename

Calbiochem^®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

technique(s)

cell culture | mammalian: suitable

颜色

white

溶解性

water: 1 mg/mL

运输

ambient

储存温度

15-25°C

SMILES string

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

InChI key

AZZMGZXNTDTSME-JUZDKLSSSA-M

安全信息

象形图

GHS08

警示用语：

Danger

危险声明

H317 - H334

预防措施声明

P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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