地塞米松，Dexamethasone [DXMS]；tested according to Ph. Eur., 99.6%

图片 地塞米松，Dexamethasone [DXMS]；tested according to Ph. Eur., 99.6%
别名：德沙美松；21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮；9α-氟-16α-甲基氢化泼尼松；9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮；(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

Empirical Formula (Hill Notation): C22H29FO5 CAS号: 50-02-2 分子量: 392.46 Beilstein: 2066651 EC 号: 200-003-9 MDL编号: MFCD00064136 PubChem化学物质编号: 329753755
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 31375
CAS号: 50-02-2
MDL号: MFCD00064136
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

地塞米松已被用作DMEM培养基补充剂，用于成骨。它也被用作α-MEM培养基补充物，以启动脂肪分化。此外，它还被用于研究细胞凋亡、细胞信号通路和基因表达。
地塞米松是一种糖皮质激素抗炎剂。它调节T细胞的存活、生长和分化。此外，地塞米松抑制一氧化氮合酶的诱导。它通过启动DNA初始切割成高分子量片段来诱导细胞凋亡。

应用

Dexamethasone has been used as a DMEM medium supplement utilized in osteogenesis. It has also been used as an alpha-MEM medium supplement to initiate adipogenic differentiation. Additionally, it has also been used to study apoptosis, cell signaling pathways and gene expression.
 

生化/生理作用

糖皮质激素抗炎剂。 调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。
Dexamethasone is a glucocorticoid anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Additionally, dexamethasone inhibits the induction of nitric oxide synthase. It induces apoptosis by initiating the initial cleavage of DNA into high molecular weight fragments.
 
 

属性

Agency

USP/NF
tested according to Ph. Eur.

质量水平

100

测定

99.6%

形式

solid

mp

262-264 °C (lit.)

溶解性

water: soluble 10mg/100 ml at 25 °C
acetone: very slightly soluble
alcohol: very slightly soluble
chloroform: slightly soluble
diethyl ether: very slightly soluble
dioxane: very slightly soluble
methanol: very slightly soluble

application(s)

pharmaceutical (small molecule)

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360FD

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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