地塞米松，Dexamethasone [DXMS]；meets USP testing specifications, 97.0-102.0%

图片 地塞米松，Dexamethasone [DXMS]；meets USP testing specifications, 97.0-102.0%
别名：德沙美松；21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮；9α-氟-16α-甲基氢化泼尼松；9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮；(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

Empirical Formula (Hill Notation): C22H29FO5 CAS号: 50-02-2 分子量: 392.46 Beilstein: 2066651 EC 号: 200-003-9 MDL编号: MFCD00064136 PubChem化学物质编号: 24894273 NACRES: NA.21
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D9184
CAS号: 50-02-2
MDL号: MFCD00064136
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说明

一般描述

一种抗炎糖皮质素，对细胞存活、细胞信号传导和基因表达具有一系列的影响。用于研究细胞凋亡、细胞信号传导通路和基因表达。
 

应用

Dexamethasone was used as medium supplement in the following studies:
  • To investigate the osteogenic differentiation and chondrogenic differentiation of bone marrow mesenchymal stem cells (MSCs).
  • In α-MEM (minimum essential medium) for inducing the osteogenic and adipogenic differentiation in mesenchymal stem cells from human bone marrow and umbilical cord blood.
  • For the isolation and characterization of mesenchymal stem cells isolated from 6- to 8-week-old C57BL/6J mice.

生化/生理作用

糖皮质激素抗炎剂。 调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。
 
 

属性

生物来源

synthetic (organic)

质量水平

200

Agency

USP/NF
meets USP testing specifications

测定

97.0-102.0%

形式

solid

mp

262-264 °C (lit.)

运输

ambient

储存温度

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360FD

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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