吗多明，Molsidomine；≥98%

图片 吗多明，Molsidomine；≥98%
持久的NO供体。鸟苷酸环化酶激活剂。别名： 脉导敏；吗导敏；脉心导敏；吗酮胺；N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10

Empirical Formula (Hill Notation): C9H14N4O4 CAS号: 25717-80-0 分子量: 242.23 EC 号: 247-207-4 MDL编号: MFCD00869301 PubChem化学物质编号: 24278544 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: M2901
CAS号: 25717-80-0
MDL号: MFCD00869301
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

持久的NO供体和血管扩张剂，需要肝脏代谢才能发挥作用。激活鸟苷酸环化酶。

应用

Molsidomine has been used as nitric oxide (NO)-releasing vasodilator to study the effect of NO on angiostatin production in aging rat kidneys.[1]
 

生化/生理作用

Molsidomine is an effective vasodilator[2] and a long-lasting nitric oxide (NO) donor.[1] It is a pro-drug that is enzymatically decarboxylated to form 3-morpholinosydnone imine (SIN-1) in the liver. Molsidomine is used as an anti-anginal agent and possesses antioxidant properties. It may be used to treat cisplatin-induced oxidative stress in the liver tissue.[2] Molsidomine has also been used during angina pectoris, heart failure, and after myocardial infarction.[3]
Orally active, long acting vasodilator; antianginal; converted by the liver to the active metabolite, SIN-1
 
 

属性

储存温度

2-8°C

SMILES string

CCOC(=O)N=C1O[N-][N+](=C1)N2CCOCC2

InChI

1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-

InChI key

XLFWDASMENKTKL-NTMALXAHSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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