双唾液酸神经节苷脂GD2来源于牛脑，Disialoganglioside-GD2 from bovine brain；~95%, lyophilized powder, semisynthetic

图片 双唾液酸神经节苷脂GD2来源于牛脑，Disialoganglioside-GD2 from bovine brain；~95%, lyophilized powder, semisynthetic
CAS号: 65988-71-8 MDL编号: MFCD00131133 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: G0776
CAS号: 65988-71-8
MDL号: MFCD00131133
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说明

双唾液酸神经节苷脂 GD2 在神经母细胞瘤、黑色素瘤和小细胞肺癌中表达。 它是一种免疫治疗靶点，也被认为是一种肿瘤相关抗原。 GD2 可能通过促进细胞生长以及细胞外基质成分的附着来促进肿瘤中的细胞迁移。

Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc
 

一般描述

Disialoganglioside GD2 is a cell surface-associated glycosphingolipid, which comprises sialic acid moiety and is regarded as a carbohydrate antigen.. It is expressed in the skin melanocytes, central and peripheral nervous system.
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
 

应用

Disialoganglioside-GD2 from bovine brain has been used:
  • in the ganglioside- enzyme-linked immunosorbent assay (ELISA)
  • in capture ELISA with anti-GD2 antibody (ch14.18)
  • as a control to test its effect on reactivating autophagy in primary fibroblasts

生化/生理作用

Disialoganglioside GD2 is expressed in neuroblastoma, melanoma and small cell lung cancer. It is an immunotherapeutic target and is also regarded as a tumor-associated antigen. GD2 may favor cell migrationin tumors by promoting cell growth, as well as extracellular matrix component attachment.
 
 

属性

质量水平

200

测定

~95%

形式

lyophilized powder

储存温度

−20°C

InChI

1S/C74H134N4O32/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-52(89)78-43(44(84)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)40-101-69-61(95)60(94)63(50(38-81)104-69)106-70-62(96)67(64(51(39-82)105-70)107-68-55(77-42(3)83)59(93)58(92)49(37-80)103-68)110-74(72(99)100)35-46(86)54(76)66(109-74)57(91)48(88)41-102-73(71(97)98)34-45(85)53(75)65(108-73)56(90)47(87)36-79/h30,32,43-51,53-70,79-82,84-88,90-96H,4-29,31,33-41,75-76H2,1-3H3,(H,77,83)(H,78,89)(H,97,98)(H,99,100)/b32-30+/t43?,44?,45-,46-,47?,48?,49-,50-,51-,53+,54+,55-,56?,57?,58+,59-,60-,61-,62-,63-,64+,65+,66+,67-,68+,69-,70+,73-,74+/m1/s1

InChI key

FFILOTSTFMXQJC-QCFYAKGBSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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