伯舒替尼，Bosutinib；≥98% (HPLC)

图片 伯舒替尼，Bosutinib；≥98% (HPLC)
别名：4-[(2,4-二氯-5-甲氧基苯基)氨基]-6-甲氧基-7-[3-(4-甲基-1-哌嗪基)丙氧基]-3-喹啉甲腈；SKI-606, 4-(2,4-Dichloro-5-methoxyphenyl)amino-6-methoxy-7-3-(4-methyl-1-piperazinyl)propoxy-3-quinolinecarbonitrile, WAY-173606

Empirical Formula (Hill Notation): C26H29Cl2N5O3 CAS号: 380843-75-4 分子量: 530.45 MDL编号: MFCD07367846 PubChem化学物质编号: 329823766 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0192
CAS号: 380843-75-4
MDL号: MFCD07367846
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,220.40

说明

一般描述

Bosutinib is a safe oral medicine with good bioavailability. It is effective for treating chronic myeloid leukemia (CML).[1] It is also a potent ATP-competitive inhibitor for Src tyrosine kinase. Bosutinib inhibits epidermal growth factor receptor (EGFR). It suppresses solid tumors associated with breast, pancreas and prostate.[2]
 

生化/生理作用

Bosutinib (SKI-606) is an orally active; dual Src/Abl tyrosine kinase inhibitor with potent antiproliferative activity. It does not appear to inhibit c-Kit and PDGRF, which are thought to be the cause of numerous side effects in anticancer treatment with some other tyrosine kinase inhibitors.
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 

其他说明

Sigma-Aldrich is a licensed supplier of Bosutinib, providing the authentic Pfizer compound. The material is independently assayed and verified by both Pfizer and Sigma-Aldrich.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

off-white to light brown

溶解性

DMSO: ≥15 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI

1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChI key

UBPYILGKFZZVDX-UHFFFAOYSA-N

Gene Information

human ... ABL1(25) , HCK(3055) , LYN(4067) , SRC(6714)

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319 - H413

预防措施声明

P273 - P305 + P351 + P338

危险分类

Aquatic Chronic 4 - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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