人脱铁转铁蛋白 [人转铁蛋白]，apo-Transferrin human；≥95% protein basis (biuret)

Transferrin is a bilobed glycoprotein containing an N-terminal lobe and a C-terminal lobe. Each of these domains is divided into two sub-domains and within the inter subdomain cleft is the metal-binding site. A single transferrin molecule can bind to two ferric ions. Apo-transferrin is an iron-free form.[1]

 

转铁蛋白可以强烈抑制细菌与生物材料的粘附，包括聚苯乙烯、聚甲基丙烯酸甲酯和硅氧烷。在培养基中，20 ug/ml 可以观察到抑制作用 。 [2]

apo-Transferrin human has been used in Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 to culture:

• pancreatic ductal adenocarcinoma (PDAC) cell lines[3]
• oligodendrocytes[4]
• renal proximal tubule epithelial cells (RPTEC/TERT1) cells[5]

Transferrin transports iron through receptor-mediated endocytosis. The iron transport mechanism occurs in the endothelial cells of the blood-brain barrier. Transferrin maintains iron homeostasis[1] and is an iron-associated marker. Reduced levels of transferrin are observed in severe COVID-19 conditions.[6] It may bind to other molecules apart from iron, hence it can be used in targeted drug delivery.[1]

 

非血红素铁转运蛋白。