两性霉素B来源于链霉菌属，Amphotericin B from Streptomyces sp；BioReagent, suitable for cell culture, ~80% (HPLC)

图片 两性霉素B来源于链霉菌属，Amphotericin B from Streptomyces sp；BioReagent, suitable for cell culture, ~80% (HPLC)
别名：Fungizone；Empirical Formula (Hill Notation): C47H73NO17 CAS号: 1397-89-3 分子量: 924.08 Beilstein: 78342 EC 号: 215-742-2 MDL编号: MFCD00877763 PubChem化学物质编号: 24890655 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: A2411
CAS号: 1397-89-3
MDL号: MFCD00877763
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

化学结构：多烯
两性霉素B是来自链霉菌属（Streptomyce sp。）的多烯抗真菌抗生素。它对真菌和细菌细胞膜的甾醇，特别是麦角甾醇具有高亲和力。维持抗真菌细胞培养物的正常用量为2.5 mg/L，培养基中使用青霉素和链霉素。

一般描述

Chemical structure: polyene
 

应用

Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.
 

生化/生理作用

两性霉素B可与甾醇结合，在膜中形成孔，并导致小分子的泄漏。该产品对真菌和酵母最有效。
 

注意

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
 

制备说明

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture.
 
 

属性

生物来源

Streptomyces sp.

质量水平

300

产品线

BioReagent

测定

~80% (HPLC)

形式

solid

效能

>750.00 μg per mg (Dry basis)

technique(s)

cell culture | mammalian: suitable

颜色

yellow to yellow-orange

溶解性

H2O: slightly soluble

抗生素抗菌谱

fungi
yeast

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES string

C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H372

危险分类

STOT RE 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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