两性霉素B来源于链霉菌属，Amphotericin B from Streptomyces sp；~80% (HPLC), powder

图片 两性霉素B来源于链霉菌属，Amphotericin B from Streptomyces sp；~80% (HPLC), powder
别名：Fungizone；Empirical Formula (Hill Notation): C47H73NO17 CAS号: 1397-89-3 分子量: 924.08 Beilstein: 78342 EC 号: 215-742-2 MDL编号: MFCD00877763 PubChem化学物质编号: 57653841 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: A4888
CAS号: 1397-89-3
MDL号: MFCD00877763
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说明

化学结构：多烯
两性霉素B用于研究钙流入对抗真菌活性的影响，并研究两性霉素B与单层，水溶液和磷脂双层中甾醇的结合和动力学。它也常用于组织培养中作为抗真菌补充剂。

来自Streptomyces sp。的两性霉素B。已被作为-
1、两性霉素穿孔贴片技术
2、作为MIC（最小抑菌浓度）琼脂稀释测定期间的参考抗真菌药物
3、作为Arcobacter选择性分离肉汤的一个组成部分

一般描述

Chemical structure: polyene
 

应用

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-
  • for amphotericin perforated patch technique
  • as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay
  • as a component of Arcobacter selective isolation broth

生化/生理作用

两性霉素B可与甾醇结合，在膜中形成孔，并导致小分子的泄漏。该产品对真菌和酵母最有效。
 

注意

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
 

制备说明

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Keep in a dry place.
 
 

属性

生物来源

Streptomyces sp.

质量水平

300

测定

~80% (HPLC)

形式

powder

颜色

yellow to orange

溶解性

DMF: 2-4 mg/mL
DMSO: 30-40 mg/mL
H2O: insoluble

抗生素抗菌谱

fungi
yeast

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES string

C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H372

危险分类

STOT RE 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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