两性霉素B三水合物，Amphotericin B trihydrate；VETRANAL®, analytical standard

图片 两性霉素B三水合物，Amphotericin B trihydrate；VETRANAL®, analytical standard
别名：Fungizone；Empirical Formula (Hill Notation): C47H73NO17 · 3H2O CAS号: 1397-89-3 分子量: 978.12 EC 号: 215-742-2 MDL编号: MFCD25541905 PubChem化学物质编号: 329757050 NACRES: NA.24
制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco
货号（SKU）: 46006
CAS号: 1397-89-3
MDL号: MFCD25541905
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

两性霉素B是来自链霉菌属（Streptomyce sp。）的多烯抗真菌抗生素。它对真菌和细菌细胞膜的甾醇，特别是麦角甾醇具有高亲和力。维持抗真菌细胞培养物的正常用量为2.5 mg/L，培养基中使用青霉素和链霉素。
作用方式：两性霉素B与甾醇结合，在膜中形成通道，并导致小分子泄漏。
抗菌谱：该产品对真菌和酵母最有效。

应用

Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
 

生化/生理作用

Mode of Action: Amphotericin B binds to sterols, forming channels in the membrane, and causing small molecules to leak out.
Antimicrobial Spectrum: The product is most effective against fungi and yeast.
 

注意

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
 

制备说明

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.
 

法律信息

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH
 
 

属性

等级

analytical standard

质量水平

200

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

格式

neat

储存温度

2-8°C

SMILES string

O[C@]1(C[C@H](O)[C@@H](C(O)=O)[C@@]2([H])O1)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(O[C@H]([C@@H]([C@@H]([C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)C2)O)C)C)=O.O.O.O

InChI

1S/C47H73NO17.3H2O/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56;;;/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60);3*1H2/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+;;;/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+;;;/m0.../s1

InChI key

QEWGLCMWTBNETQ-KCPNHEJKSA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H372

危险分类

STOT RE 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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