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马兜铃酸I,Aristolochic acid I;powder

别名:TR 1736;Empirical Formula (Hill Notation): C17H11NO7 CAS号: 313-67-7 分子量: 341.27 EC 号: 206-238-3 MDL编号: MFCD00004996 PubChem化学物质编号: 24890982 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A5512
CAS号: 313-67-7
MDL号: MFCD00004996
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说明

一般描述

Aristolochic acid is a naturally occurring plant metabolite found in Aristolochia sp, Bragantia sp. or Asarum sp. plants.[1] It comprises a mixture of nitrophenanthrene carboxylic acids such as aristolochic acid I and II.[2]
 

应用

马兜铃酸I是一种有效的磷脂酶A2 抑制剂。 马兜铃酸I可诱导大鼠肾脏中的肿瘤形成和人肾脏近端小管上皮细胞的凋亡。
Aristolochic acid I have been used:
  • as a standard for the analysis of Aristolochia sprucei crude extract by high-performance liquid chromatography[3]
  • to study its effects on histone deacetylase 3 (HDAC3) aberration and renal fibrosis[4]
  • to induce acute aristolochic acid nephropathy and to study its impact on miRNA and mRNA expression in mice[5]

生化/生理作用

Aristolochic acid is a potent inhibitor of phospholipase A2 (PLA2), hyaluronidase, and acetylcholinesterase plasma proteases from snake venoms.[6] Aristolochic acid is considered a herbal medicine and shows therapeutic effects against obstetrics, snake bites, gout, and rheumatism.[2] It exhibits anti-inflammatory and anti-malarial properties.[7] In addition, it is also considered a genotoxic mutagen[2] and causes aristolochic acid nephropathy (AAN), characterized by interstitial fibrosis and urothelial cancer.[2]
有效的磷脂酶A2 抑制剂,包括钙离子载体诱导的嗜中性粒细胞磷脂酶A2 活性。实验动物模型的肾肿瘤引发剂。
 
 

属性

测定

≥90% (HPLC)

形式

powder

颜色

yellow

mp

269-270 °C

溶解性

DMSO: soluble
ethanol: soluble

储存温度

2-8°C

SMILES string

COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O

InChI

1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)

InChI key

BBFQZRXNYIEMAW-UHFFFAOYSA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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