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霉酚酸 [麦考酚酸],Mycophenolic acid [MPA];≥95% (HPLC), Calbiochem®

别名:麦可酚酸;6-(1,3-二氢-7-羟基-5-甲氧基-4-甲基-1-氧代异苯并呋喃-6-基)-4-甲基-4-己酸;6-(4-羟基-6-甲氧基-7-甲基-3-氧代-5-酞酰)-4-甲基-4-己烯酸; 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid;6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid;NSC 129185

CAS号 24280-93-1 经验分子式(希尔表示法) C17H20O6 分子量 320.34 MDL number MFCD00036814
货号(SKU): 475913
CAS号: 24280-93-1
MDL号: MFCD00036814
增值税发票 √ 免费货运 [顺丰 联邦] √
¥1,254.80

产品描述

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.

一种免疫抑制剂,可通过抑制肌苷单磷酸脱氢酶来抑制嘌呤核苷酸从头合成,并防止XMP和GMP的形成。

General description

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

包装

100, 500 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inosine monophosphate dehydrogenase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
Senda, M., et al. 1995. Transplantation60, 1143.
Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res.204, 241.
Falkner, F.G., and Moss, B. 1988. J. Virol.62, 1849.
Cohen, M.B., et al. 1981. J. Biol. Chem.256, 8713.
Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA78, 2072.

性质

Quality Level100
assay≥95% (HPLC)
formsolid
mfr. no.Calbiochem®
storage conditionOK to freeze
storage conditions+15C to +30C
colorwhite to off-white
solubility0.1 M NaOH: 10 mg/mL
ethanol: soluble
shipped inambient
InChI1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI keyHPNSFSBZBAHARI-RUDMXATFSA-N


安全信息

信号词 Danger
靶器官 Immune system
危害码 (欧洲) T,N
风险声明 (欧洲) 61-22-48/25-50/53-68
安全声明 (欧洲) 53-22-45-61
RIDADR UN 3077 9 / PGIII
WGK德国 WGK 3
RTECS MP8050000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55
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