雷帕霉素，Rapamycin；VETRANAL®, analytical standard

图片 雷帕霉素，Rapamycin；VETRANAL®, analytical standard
别名：雷帕霉素标准品；西罗莫司；Sirolimus；23,27-环氧-3H-吡啶并[2,1-c][1,4]氧杂氮杂环苯三胺；23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine；AY 22989；mTOR Inhibitor I

Empirical Formula (Hill Notation): C51H79NO13 CAS号: 53123-88-9 分子量: 914.17 MDL编号: MFCD00867594 PubChem化学物质编号: 329755624 NACRES: NA.24
制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco
货号（SKU）: 37094
CAS号: 53123-88-9
MDL号: MFCD00867594
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

雷帕霉素属于从吸湿链霉菌中获得的大环内酯类抗生素。它最初被用作抗真菌剂，但后来也被用作免疫抑制剂和潜在的抗癌药物。它通过阻止丝氨酸/苏氨酸激酶的活性并随后阻断细胞因子驱动的T细胞增殖而起作用。

一般描述

Rapamycin belongs to the macrolide class of antibiotics obtained from the bacterium Streptomyces hygroscopicus. It was first used as an anti-fungal agent but later also found use as an immunosuppressant and potential anti-cancer drug. It acts by preventing the activity of serine/threonine kinase and subsequently blocking the cytokine-driven T cell proliferation.
 

应用

The analytical standard can be used as follows:
  • Electrochemical determination of rapamycin using boron-doped diamond electrode and differential pulse voltammetry (DPV) in human urine, serum, and blood samples
  • Simultaneous determination of six immunosuppressants from whole blood samples by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) technique combined with modified QuEChERS method

其他说明

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
 

法律信息

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH
 
 

属性

等级

analytical standard

质量水平

100

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

储存温度

−20°C

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

InChI

1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI key

QFJCIRLUMZQUOT-HPLJOQBZSA-N

Gene Information

human ... FKBP1A(2280)

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H351 - H361fd

危险分类

Carc. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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