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阿替美唑,Atipamezole;≥98% (HPLC)

别名:Antisedan;4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-Imidazole;MPV 1248

Empirical Formula (Hill Notation): C14H16N2 CAS号: 104054-27-5 分子量: 212.29 MDL编号: MFCD00864502 PubChem化学物质编号: 329771055 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A9611
CAS号: 104054-27-5
MDL号: MFCD00864502
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$192.56

说明

一种α2-肾上腺素受体拮抗剂。

一般描述

Atipamezole has an imidazole structure and gets localized in the central nervous system on administration.
 

应用

Atipamezole has been used as a α2-adrenoceptor antagonist in mesencephalic trigeminal nucleus (MTN) neurons, CD4+ T-lymphocyte and human embryonic kidney (HEK293) membrane preparation.
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

Atipamezole is a selective α2 adrenergic blocker. Atipamezole is more potent than yohimbine; it is very selective for α2 adrenergic vs αsites, but not selelctive for α2 subtypes.
Atipamezole elicits affinity towards adrenoreceptor subtypes namely α2A, α2B and α2C. High levels of atipamezole impairs cognitive functions. It also reverses the adrenoreceptor agonist functionalities. Atipamezole shows no affinity towards muscarinic and dopamine or neurotransmitter receptors. Atipamezole when used along with morphine elicits antinociceptive effects.
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to brown

溶解性

DMSO: ≥30 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

CCC1(Cc2ccccc2C1)c3cnHcn3

InChI

1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)

InChI key

HSWPZIDYAHLZDD-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16