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阿仑膦酸钠三水合物 [阿屈膦酸钠三水],Alendronate sodium trihydrate;≥97% (NMR), powder

别名:4-氨基-1-羟基-1-膦酸丁酯单钠, MK-217;4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217

Empirical Formula (Hill Notation): C4H12NaNO7P2 · 3 H2O CAS号: 121268-17-5 分子量: 325.12 MDL编号: MFCD01748233 PubChem化学物质编号: 24724391 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A4978
CAS号: 121268-17-5
MDL号: MFCD01748233
增值税发票 √ 技术支持 √ 质量保障 √ 电话:13910327035
¥2,923.30

说明

应用

阿仑膦酸钠三水合物是一种骨吸收抑制剂,法尼基二磷酸合成酶抑制剂和 CD45 蛋白酪氨酸磷酸酶抑制剂。
Alendronate sodium trihydrate has been used:
  • for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
  • in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
  • to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis[1]

生化/生理作用

Alendronate is a nitrogen-containing bisphosphonate[1] that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.
阿仑膦酸钠三水合物是一种骨吸收抑制剂;法尼基二磷酸合成酶抑制剂 (IC 50 = 460 nM);CD45 蛋白酪氨酸磷酸酶抑制剂。
 
 

属性

质量水平

测定

≥97% (NMR)

形式

powder

颜色

white

溶解性

water, double-distilled: 10 mg/mL

储存温度

−20°C

SMILES string

[Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

InChI

1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChI key

DCSBSVSZJRSITC-UHFFFAOYSA-M

Gene Information

human ... FDPS(2224)

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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