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锯鳞蝰素 [锯鳞肽],Echistatin from Echis carinatus;lyophilized powder, γ-irradiated, BioXtra, >95% (SDS-PAGE)

别名:锯鳞蝮蝰蛇毒锯鳞蝰素;锯鳞血抑肽;棘皮抑素;CAS号: 129038-42-2 MDL编号: MFCD00081572 NACRES: NA.75
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): E1518
CAS号: 129038-42-2
MDL号: MFCD00081572
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¥5,750.00

说明

一般描述

Echistatin is a small peptide disintegrin that has no multiple epitopes.[1] It is a single chain polypeptide with a molecular mass of 5400. Echistatin has eight cysteines and the sequence arginine glycine aspartic acid (RGD).[2]
 

应用

Echistatin from Echis carinatus has been used in diabetic rabbits grouping and treatment[3] and murine iPSC (induced pluripotent stem cell) culture.[4]
 

生化/生理作用

Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1).[1] Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.[2]
Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.
 
 

属性

生物来源

Echis carinatus

质量水平

sterility

γ-irradiated

产品线

BioXtra

测定

>95% (SDS-PAGE)

形式

lyophilized powder

分子量

5.2-5.4 kDa

technique(s)

cell culture | mammalian: suitable

溶解性

water: soluble 0.1 mg/mL, clear, colorless

运输

ambient

储存温度

−20°C

InChI key

XLBBKEHLEPNMMF-SSUNCQRMSA-N

 

安全信息

监管信息

常规特殊物品
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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