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金霉素盐酸盐 [盐酸金霉素],Chlortetracycline hydrochloride;BioReagent, suitable for fluorescence, from Streptomyces aureofaciens, ≥97.0% (AT)

别名:氯四环素盐酸盐;金霉素盐酸盐;金黴素;7-Chlorotetracycline hydrochloride

CAS号 64-72-2 经验分子式(希尔表示法) C22H23ClN2O8 · HCl 分子量 515.34 Beilstein/REAXYS Number 3858364 EINECS 编号 200-591-7 MDL number MFCD00082440 PubChem Substance ID 57648175 NACRES NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 26430
CAS号: 64-72-2
MDL号: MFCD00082440
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974,00 kr

产品描述

General description

Chemical structure: tetracycline

Application

Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

Biochem/physiol Actions

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.
Mode of Resistance: Loss of cell wall permeability.

包装

5 g, 25 g, 100g

Quality

Recommended for fluorescent studies of calcium signaling in cells or tissues.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

性质

biological sourceStreptomyces aureofaciens
product lineBioReagent
assay≥97.0% (AT)
formsolid
impurities≤3% water
colorfaintly yellow to yellow
mp210-215 °C (dec.) (lit.)
solubilityH2O: 50 mg/mL
fluorescenceλex 392 nm; λem 536 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+
suitabilitysuitable for fluorescence
Mode of actionprotein synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
storage temp.−20°C
SMILES stringCl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O
InChI1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1
InChI keyCBHYYLPALVVVEY-LYNLVHCPSA-N


安全信息

符号
信号词 Warning
靶器官 Respiratory system
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xi
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26
RIDADR NONH for all modes of transport
WGK德国 WGK 2
RTECS QI7800000
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32