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重组人Raf-1蛋白激酶,Raf-1 Protein Kinase human;recombinant, expressed in E. coli, ~20 units/mg protein

Raf-1蛋白激酶来源于人类,MDL number MFCD04041081 NACRES NA.54;人重组Raf-1蛋白激酶
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): R3652
MDL号: MFCD04041081
增值税发票 √ 技术支持 √ 质量保障 √ 电话:13910327035
¥8,981.05

说明

应用

Raf-1 is a serine/threonine protein kinase which is involved in the MAPK signal transduction pathway, a pathway that is involved in the development and progression of cancer. Raf-1 kinases are used to study potential cancer treatments as well as the responses to cancer treatments [1].
 

生化/生理作用

Raf-1 activates the protein kinases MEK1 and MEK2. MEK1 and MEK2 are phosphorylated to activate protein kinases ERK1 and ERK2. Activated ERKs play an important role in cell division, apoptosis, cell differentiation, and cell migration [2].
 

单位定义

One unit will activate MEK B substrate by 10% per min at pH 7.0 at 30 °C.
 

外形

Solution in 50 mM Tris-HCl, pH 7.0 buffer containing 14 mM β-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 10% glycerol.
 
 

属性

重组

expressed in E. coli

质量水平

形式

solution

specific activity

~20 units/mg protein

分子量

74 kDa

UniProt登记号

相关疾病

cancer

运输

dry ice

储存温度

−70°C

Gene Information

human ... RAF1(5894)

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 1

商品规格
属性名称属性值
储存温度 Storage temp.-70°C超低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16