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重组人醌氧化还原酶2,Quinone Oxidoreductase 2 (NQO2) human;recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein

别名:NQO2 human, NRH nitroreductase human, NRH quinone reductase human

MDL编号: MFCD03458332 NACRES: NA.54
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): Q0380
MDL号: MFCD03458332
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¥6,555.97

说明

醌氧化还原酶 2 已被用于一项研究,以调查最近在限制百草枯毒性方面的进展是否使其更安全地用作除草剂。醌氧化还原酶 2 也已用于研究化疗药物 CB1954 的 NQO2 介导的毒性的研究。
Sigma的产品已被用于鉴定NQO2酶的新型抑制剂。它也被用于研究阿非巴唑对醌还原酶2活性的影响。

NQO2活性的调节可对肿瘤抑制因子p53的水平和功能产生影响。NQO2的缺失可以通过NF-κB途径改变细胞内信号传导。
独特的人氧化还原酶,使用二氢烟酰胺核苷(NRH)作为共底物,而不是NAD(P)H.激活抗癌前药。推定的褪黑激素受体。

应用

Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2.[1] It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.[2]
 

生化/生理作用

Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.[1]
Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.
 

单位定义

One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.
 

外形

contains 10% PBS buffer salts
 
 

属性

重组

expressed in E. coli

质量水平

测定

≥90% (SDS-PAGE)

形式

lyophilized powder (one vial contains one mg protein)

specific activity

≥100 units/mg protein

UniProt登记号

储存温度

−20°C

Gene Information

human ... NQO2(4835)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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