一般描述
表皮生长因子(EGF)在Henle′s环和肾远曲小管中合成。它也在唾液腺和十二指肠中产生。
表皮生长因子(EGF)是小的促有丝分裂多肽(∼6 6 kDa),存在于许多哺乳动物物种中,分布在许多组织和体液中。†人EGF与β-尿抑胃素相同,β-尿抑胃素是基于其胃酸分泌抑制能力而被识别和分离的多肽。† EGF是生长因子家族的成员,其特征在于存在6个保守的半胱氨酸基序,形成了三个二硫键。重组人EGF中3个链内二硫键的位置与小鼠EGF的位置相同。†EGF与牛痘病毒19 kDa蛋白中包含的序列同源,† 该病毒可能利用EGF受体进入细胞† EGF对多种表皮和上皮细胞具有促有丝分裂作用,包括成纤维细胞、神经胶质细胞、乳腺上皮细胞、血管和角膜内皮细胞、牛粒层细胞、兔软骨细胞、HeLa细胞和SV40-3T3细胞。†
引用
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5.Blomquist, M.C. et al., Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. Proc. Natl. Acad. Sci. USA, 81, 7363-7367 (1984).
6.Eppstein, D.A. et al., Epidermal growth factor receptor occupancy inhibits vaccinia virus infection. Nature, 318, 663-665 (1985).