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那氟沙星 [纳迪沙星],Nadifloxacin;≥98% (HPLC)

别名:纳迪沙星;9-氟-6,7-二氢-8-(4-羟基-1-哌啶基)-5-甲基-1-氧代-1H, 5H-苯并[ij]喹啉-2-羧酸;金氧氟沙星;9-氟-7,7-二羟基-8-(-4-羟基-1-哌啶基)-5-乙基-1-氧代-1 H,5H苯并[ij]喹啉-2-甲酸;Nadifloxacin, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, Acuatim, Jinofloxacin, OPC-7251, 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid

Empirical Formula (Hill Notation): C19H21FN2O4 CAS号: 124858-35-1 分子量: 360.38 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SMB00375
CAS号: 124858-35-1
MDL号: MFCD00865081
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¥614.56

说明

化学结构:氟喹诺酮
纳迪沙星本质上是抗菌的,是一种氟化的喹诺酮类药物。它对革兰氏阴性和革兰氏阳性细菌,尤其是丙酸杆菌痤疮具有很强的抵抗力。
纳迪沙星被用作局部抗菌剂,由于其能够防止细菌DNA的负超螺旋,因此具有杀菌作用。DNA超螺旋、复制和转录由DNA旋转酶催化。在日本,它被用于治疗皮肤感染和痤疮。研究表明,纳地沙星能够成功治疗由铜绿假单胞菌引起的绿指甲综合征(GNS)。

一般描述

Chemical structure: fluoroquinolone
Nadifloxacin is antimicrobial in nature, and is a fluorinated quinolone. It is highly potent against Gram-negative and Gram-positive bacteria, especially Propionibacteruim acnes.
 

生化/生理作用

Nadifloxacin is used as a topical antibacterial, which is bactericidal due to its capability of preventing the negative supercoiling of bacterial DNA. DNA supercoiling, replication, transcription are catalyzed by DNA gyrase. In Japan, it is used to treat skin infection and acne. Studies show, that nadifloxacin is capable of successfully treating green nail syndrome (GNS) caused by Pseudomonas aeruginosa.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510): Non Combustible Solids
 
 

属性

生物来源

synthetic (Organic)

质量水平

200

测定

≥98% (HPLC)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510) Non Combustible liquids.)

颜色

white to yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

DNA synthesis | interferes
enzyme | interferes

储存温度

−20°C

InChI

1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)

InChI key

JYJTVFIEFKZWCJ-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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