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贝曲西班,Betrixaban;≥98% (HPLC)

别名:MK-4448, MLN1021, N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide, N-(5-Chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, PRT-054021, PRT054021

CAS号 330942-05-7 经验分子式(希尔表示法) C23H22ClN5O3 分子量 451.91 MDL number MFCD16038040
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2845
CAS号: 330942-05-7
MDL号: MFCD16038040
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¥869.21

产品描述

一种口服有效的选择性的factor Xa (fXa)抑制剂。

Biochem/physiol Actions

Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 μM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC50 >10 μM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 2 mg/mL, clear
storage temp.  2-8°C
SMILES string  ClC1=CN=C(C=C1)NC(C2=C(NC(C3=CC=C(C(N(C)C)=N)C=C3)=O)C=CC(OC)=C2)=O


安全信息

符号 
信号词 Warning
危害声明 H302 - H373
警示性声明 P301 + P312 + P330 - P314
靶器官 Blood
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32