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诺地尼-1,Nodinitib-1 [ML130];≥98% (HPLC)

别名:1-[(4-甲基苯基)磺酰基]-1H-苯并咪唑-2-胺;1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130

CAS号 799264-47-4 经验分子式(希尔表示法) C14H13N3O2S 分子量 287.34 MDL number MFCD04322367 PubChem Substance ID 329825379 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0379
CAS号: 799264-47-4
MDL号: MFCD04322367
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$255.95

产品描述

一种有效的选择性的核苷酸结合寡聚域样受体1(NOD1)抑制剂.IC50:0.56 μM.

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.

Nodinitib-1(ML130)是核苷酸低聚结构域(NOD)-1受体的选择性抑制剂,该酶参与先天性免疫应答,并与几种炎症性疾病有关。 NOD1和NOD2识别细菌肽聚糖衍生的不同结构,并直接激活NF-κB通路,该通路控制促炎分子的产生。 与NOD2相比,Nodinitib-1对NOD1的选择性为40:1。

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: >10 mg/mL
storage temp.  2-8°C
SMILES string  Cc1ccc(cc1)S(=O)(=O)n2c(N)nc3ccccc23
InChI  1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChI key  SRFABRWQVPCPRG-UHFFFAOYSA-N


安全信息

危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16