sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

诺司卡品,(S,R)-Noscapine [HSDB3372, NSC5366];97%

别名:那可丁,(S)-6,7-dimethoxy-3-((R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

CAS号 128-62-1 经验分子式(希尔表示法) C22H23NO7 分子量 413.42 EINECS 编号 204-899-2 MDL number MFCD00069316 PubChem Substance ID 24862408 NACRES NA.22
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 363960
CAS号: 128-62-1
MDL号: MFCD00069316
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥626.00

产品描述

一种中枢作用的镇咳剂。由其σ-受体激动剂活性介导,并具有抗癌活性。

General description

(S,R)-Noscapine is a phthalideisoquinoline alkaloid found in opium. It is an antimicrotubule agent that also shows potent antitumor activity.[1]

Application

Noscapine may be used as a source to synthesize its bromo-derivatives, which has higher tubulin binding activity when compared to noscapine.[1] Its 3,4,5-trimethoxybenzyl analog is a potential antitumor agent.[2]

包装

5 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 363960.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

性质

Quality Level  100
assay  97%
optical activity  [α]20/D −200°, c = 1 in chloroform
mp  174-176 °C (lit.)
SMILES string  COc1ccc2C(OC(=O)c2c1OC)C3N(C)CCc4cc5OCOc5c(OC)c34
InChI  1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1
InChI key  AKNNEGZIBPJZJG-MSOLQXFVSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302 - H336
警示性声明 P301 + P312 + P330
靶器官 Central nervous system
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS RD2625000
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16