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补骨脂酚,Bakuchiol;≥95%

别名:4-[(1E,3S)-3-乙烯基-3,7-二甲基-1,6-辛二烯-1-基]苯酚;(S)-补骨脂酚;(S)-Bakuchiol, 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol

Empirical Formula (Hill Notation): C18H24O CAS号: 10309-37-2 分子量: 256.38 Beilstein: 3611720 MDL编号: MFCD01707441 PubChem化学物质编号: 329825075
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SMB00604
CAS号: 10309-37-2
MDL号: MFCD01707441
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说明

补骨脂酚 (BAK) 是从补骨脂的果实和种子中提取的酚类二萜化合物。 它也可以在豆科植物家族的其他植物和花卉中找到。

补骨脂酚 (BAK) 具有多种药理作用,如抗氧化、抗衰老、抗炎、抗菌、抗糖尿病、心脏保护和雌激素样作用。 已知它具有相似的功效,但在改善光老化方面比视黄醇具有更好的耐受性。 补骨脂酚对口腔微生物如变形链球菌具有抗菌活性。 它也是一种 DNA 聚合酶抑制剂,在人肺腺癌细胞 A549 中显示出抗肿瘤活性。 Bakuchiol 在体外和体内均显示出对大鼠肝损伤的保肝活性。

一般描述

Bakuchiol (BAK) is a phenolic meroterpene compound extracted from the fruits and seeds of Psoralea corylifolia. It can also be found in other plants and flowers from the Leguminosae plant family.
 

应用

Bakuchiol has been used as a reference standard to detect its existence in Psoralea corylifolia L. (PC) using ultra-performance liquid chromatography.
 

生化/生理作用

Bakuchiol (BAK) has various pharmacological effects such as antioxidant, antiaging, anti-inflammatory, anti-bacterial, anti-diabetic, cardioprotective, and estrogen-like effects. It is known to have similar efficacy but to be better-tolerated than retinol in improving photoaging. Bakuchiol displays antimicrobial activity against oral microorganisms such as Streptococcus mutans. It is also a DNA polymerase inhibitor and showed anti-tumor activity in human lung adenocarcinoma A549 cells. Bakuchiol has displayed hepatoprotective activity against rat liver damage in both in vitro and in vivo.
 
 

属性

质量水平

200

测定

≥95%

形式

liquid

储存温度

−20°C

SMILES string

C\C(C)=C/CC[C@@](C)(C=C)\C=C\c1ccc(O)cc1

InChI

1S/C18H24O/c1-5-18(4,13-6-7-15(2)3)14-12-16-8-10-17(19)11-9-16/h5,7-12,14,19H,1,6,13H2,2-4H3/b14-12+/t18-/m1/s1

InChI key

LFYJSSARVMHQJB-QIXNEVBVSA-N

 

安全信息

储存分类代码

10 - Combustible liquids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10
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