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补骨脂乙素,Isobavachalcone;phyproof® Reference Substance, ≥98.0% (HPLC)

别名:紫罗兰素;异巴查耳酮;(2E)-1-[2,4-二羟基-3-(3-甲基-2-丁烯基)苯基]-3-(4-羟基苯基)-2-丙烯-1-酮;2',4,4'-三羟基-3'-(3-甲基-2-丁烯基)-查尔酮;Corylifolinin, Isobacachalcone, (2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one, 2′,4,4′-Trihydroxy-3′-(3-methyl-2-butenyl)-chalcone

Empirical Formula (Hill Notation): C20H20O4 CAS号: 20784-50-3 分子量: 324.37 MDL编号: MFCD00902090
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PHL83317
CAS号: 20784-50-3
MDL号: MFCD00902090
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说明

补骨脂乙素是一种从多用途药用植物补骨脂中分离出来的查尔酮,可抑制 LPS 诱导的 ICAM-1 表达和白细胞与脑内皮细胞的粘附。 似乎异巴伐查耳酮调节 Toll 样受体 4 (TLR4) 的 MyD88 依赖性和 TRIF 依赖性信号传导。 补骨脂乙素显着抑制 Aβ42 的寡聚化和原纤维化。 异巴伐查耳酮具有广泛的生物活性,包括抗氧化、抗血小板、抗菌、抗炎、抗肿瘤和神经保护。

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
 

生化/生理作用

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears that isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.
 

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG
 
 

属性

等级

primary reference standard

产品线

phyproof® Reference Substance

测定

≥98.0% (HPLC)

manufacturer/tradename

PhytoLab

application(s)

food and beverages

格式

neat

储存温度

2-8°C

SMILES string

OC1=C(CC=C(C)C)C(O)=C(C(/C=C/C2=CC=C(O)C=C2)=O)C=C1

InChI

1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+

InChI key

DUWPGRAKHMEPCM-IZZDOVSWSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
商品标签 [tags]