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葫芦素E,Cucurbitacin E;phyproof® Reference Substance, ≥95.0% (HPLC)

别名:α-Elaterin, α-Elaterine; Empirical Formula (Hill Notation): C32H44O8 CAS号: 18444-66-1 分子量: 556.69 NACRES: NA.24
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PHL80013
CAS号: 18444-66-1
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说明

葫芦素E是一种有效的肌动蛋白解聚抑制剂。 葫芦素 E 比 jasplakinolide 更活跃,并且具有不同的作用机制,与不同的位点结合。 葫芦素 E 与丝状肌动蛋白 (F-肌动蛋白) 特异性结合,在 Cys257 残基处形成共价键,但不与单体肌动蛋白 (G-肌动蛋白) 结合,稳定 F-肌动蛋白,而不影响肌动蛋白聚合或成核。

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.
 

生化/生理作用

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.
 

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG
 
 

属性

等级

primary reference standard

产品线

phyproof® Reference Substance

测定

≥95.0% (HPLC)

manufacturer/tradename

PhytoLab

application(s)

food and beverages

格式

neat

储存温度

2-8°C

InChI

1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1

InChI key

NDYMQXYDSVBNLL-MUYMLXPFSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
商品标签 [tags]