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萘普生钠,Naproxen sodium;Pharmaceutical Secondary Standard; Certified Reference Material

别名:萘普生钠标准品;(S)-6-甲氧基-α-甲基-2-萘乙酸钠盐, (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

Empirical Formula (Hill Notation): C14H13NaO3 CAS号: 26159-34-2 分子量: 252.24 EC 号: 247-486-2 MDL编号: MFCD00058507 PubChem化学物质编号: 329823182 NACRES: NA.24
货号(SKU): PHR1165
CAS号: 26159-34-2
MDL号: MFCD00058507
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥921.41

说明

一般描述

Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache.[1][2][3][4][5] Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
 

应用

Naproxen sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatographic[3][4][5] and spectrophotometric[6] techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

环加氧酶(前列腺素 H 合成酶 1 和 2)抑制剂。
 

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAA7178 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1457403

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

 

安全信息

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 1A

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
商品标签 [tags]