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苯磺酸氨氯地平，Amlodipine besylate；Pharmaceutical Secondary Standard; Certified Reference Material

别名：苯磺酸氨氯地平标准品；2-(2-氨基乙氧基)-甲基-4-(2-氯苯基)-1,4-二氢-6-甲基-3,5-吡啶二甲酸 3-乙基 5-甲酯苯磺酸酯；活络喜(抗高血压药)；Norvasc, 2-(2-Aminoethoxy)-methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate

Empirical Formula (Hill Notation): C20H25ClN2O5 · C6H5SO3H CAS号: 111470-99-6 分子量: 567.05 MDL编号: MFCD00887594 PubChem化学物质编号: 329823196 NACRES: NA.24

制造商品牌: Supelco , 西格玛 Sigma-Aldrich

货号（SKU）: PHR1185

CAS号: 111470-99-6

MDL号: MFCD00887594

技术支持 √ 增值税发票 √ 免费送货 √ 质量保障 √

目录价.SKU-Variant

1g
5g [+¥2,477.39]

¥1,282.86

数量:

说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amlodipine besylate is a calcium channel blocker, which inhibits the trans membrane influx of calcium ions into vascular smooth muscles and cardiac muscle. It belongs to the dihydropyridine family. It is used in combination with atorvastatin calcium to treat vasospastic angina, chronic stable angina, hypertension, in elevated serum triglyceride levels, primary dysbetalipoproteinemia.[1]

应用

Amlodipine besylate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][2][3] using different chromatography techniques[1][2] and spectrophotometric technique.[3]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物，作用于 Ca _V1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长，对雄性大鼠有抗生殖作用。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0717 in the slot below. This is an example certificate only and may not be the lot that you receive.

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0000049
traceable to USP 1029501

API family

amlodipine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC

InChI

1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

InChI key

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

安全信息

象形图

GHS07

警示用语：

Warning

危险声明

H302

预防措施声明

P264 - P270 - P301 + P312 - P501

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 33 \| 欧洲Eur. ≥ 27 \| 東京Tokyo ≥ 9 \| 香港与北京 ≥ 16

商品标签 [tags]

苯磺酸氨氯地平 (2)

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