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苦参酮,Kurarinone;≥98% (HPLC)

别名:(-)-Kurarinone, (2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-4H-1-benzopyran-4-one, Marini

CAS号 34981-26-5 经验分子式(希尔表示法) C26H30O6 分子量 438.51
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1843
CAS号: 34981-26-5
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¥1,753.52

产品描述

苦参根中的黄酮类成分苦参酮(Kurarinone)是强电导钙激活钾通道(BKCa通道)的有效活化剂。 Kurarinone对增强仅由α亚基组成的同型BKCa通道表现出强烈的偏好。 在大鼠OAB模型中,Kurarinone减少了乙酰胆碱引起的大鼠膀胱条的收缩,并降低了排尿频率。 Kurarinone具有细胞毒性和抗炎活性。 Kurarinone通过抑制NF-KB依赖性cFLIP表达来使TRAIL诱导的肿瘤细胞凋亡敏感。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

Kurarinone, a flavanone from Sophora flavescens roots, is a potent activator of the large-conductance calcium-activated potassium channel (BKCa channel). Kurarinone exhibits strong preference to potentiate the homomeric BKCa channel composed only of the α subunits. Kurarinone reduces acetylcholine induced contraction of rat urinary bladder strips and decreased the voiding frequency in a rat OAB model. Kurarinone exhibits cytotoxic and antiinflamatory activity. Kurarinone sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-KB-dependent cFLIP expression.

性质

Quality Level  100
biological source  (isolated from Caragana sinica)
assay  ≥98% (HPLC)
form  powder
storage condition  protect from light
color  white to beige
solubility  DMSO: 20 mg/mL, clear
storage temp.  −20°C
SMILES string  CC([C@H](CC=C(C)C)CC1=C2C(C(C[C@@H](C3=CC=C(O)C=C3O)O2)=O)=C(OC)C=C1O)=C
InChI  1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3
InChI key  XRYVAQQLDYTHCL-UHFFFAOYSA-N


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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