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苦参碱,Matrine;≥97.0% (HPLC)

别名:槐果苷;Sophocarpidine;Matridin-15-one; Empirical Formula (Hill Notation): C15H24N2O CAS号: 519-02-8 分子量: 248.36 MDL编号: MFCD00210527 PubChem化学物质编号: 329818010 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): M5319
CAS号: 519-02-8
MDL号: MFCD00210527
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说明

苦参碱 (MT) 或槐果苷是一种天然存在的生物活性化合物,从苦参和山豆根等传统中草药中提取。

已使用苦参碱:
研究其对多柔比星 (DOX) 诱导的小鼠模型和 H9C2 细胞心脏毒性的抗氧化和保护作用
作为一种化学治疗剂,以测试其对人多形性胶质母细胞瘤 (GBM) 细胞和卵巢癌细胞生长的抑制作用
研究其对 HepG2 细胞线粒体分裂的影响及其抗肿瘤功能
作为胆管癌 (CCA) 细胞系中的坏死性凋亡诱导剂

苦参碱是一种有效的治疗剂,具有多种药理作用,如抗癌、抗菌、抗纤维化、抗炎特性。它是一种巨胞饮作用诱导剂,可降低细胞三磷酸腺苷 (ATP) 水平。苦参碱也可作为有效的镇静剂。它在 2,4,6-三硝基苯磺酸 (TNBS) 诱导的小鼠肠道炎症中用作抗炎剂。它的作用是逆转 Warburg 效应并抑制人类结肠癌细胞的生长。
苦参碱是一种生物碱,是皂荚植物根部的主要成分之一。苦参碱对乙型和丙型肝炎可能的抗病毒功效以及对某些皮肤病和癌症的影响进行了研究。

一般描述

Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.
 

应用

Matrine has been used:
  • to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells
  • as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells, and ovarian cancer cells
  • to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells
  • as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines
 

生化/生理作用

Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties. It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level. Matrine may also serve as an effective sedative agent. It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice. It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.
Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.
 
 

属性

质量水平

100

储存温度

2-8°C

SMILES string

O=C1CCCC2C3CCCN4CCCC(CN12)C34

InChI

1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1

InChI key

ZSBXGIUJOOQZMP-JLNYLFASSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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