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花生四烯酸乙酯,Ethyl arachidonate;≥98.5% (GC), liquid

别名:5,8,11,14-二十碳四烯酸乙酯;花生四烯酸乙酯;5,8,11,14-Eicosatetraenoic acid ethyl ester, Arachidonic acid ethyl ester

Empirical Formula (Hill Notation): C22H36O2 CAS号: 1808-26-0 分子量: 332.52 MDL编号: MFCD00038340 PubChem化学物质编号: 24891398 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A9135
CAS号: 1808-26-0
MDL号: MFCD00038340
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€205.62

说明

花生四烯酸 (AA) 是细胞膜磷脂的不饱和 omega-6 脂肪酸成分。 磷脂酶 A2 响应炎症从膜磷脂中释放 AA。 AA 随后通过至少两种环氧合酶 (COX) 异构体代谢为前列腺素和血栓烷,通过脂氧合酶代谢为白三烯和脂氧素,并通过 p450 催化代谢为环氧二十碳三烯酸。 AA 及其代谢物在多种生物过程中发挥重要作用,包括信号转导、收缩、趋化以及细胞增殖、分化和凋亡。 AA 已被证明与 G 蛋白的 α 亚基结合并抑制 Ras GTPase 激活蛋白 (GAP) 的活性。 AA 的细胞摄取是能量依赖性的,并且涉及蛋白质促进的跨质膜转运。
 

生化/生理作用

Arachidonic acid (AA) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, contraction, chemotaxis, and cell proliferation, differentiation and apoptosis. AA has been demonstrated to bind to the α subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
 
 

属性

生物来源

fungus

质量水平

100

测定

≥98.5% (GC)

形式

liquid

官能团

ester

运输

ambient

储存温度

−20°C

SMILES string

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC

InChI

1S/C22H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h8-9,11-12,14-15,17-18H,3-7,10,13,16,19-21H2,1-2H3/b9-8-,12-11-,15-14-,18-17-

InChI key

SNXPWYFWAZVIAU-GKFVBPDJSA-N

 

安全信息

个人防护装备

Eyeshields, Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16