非诺班，Fenobam；≥98% (HPLC), solid

图片 非诺班，Fenobam；≥98% (HPLC), solid
别名：芬巴姆；氯苯咪脲；N-（3-氯苯基）-N′-（4,5-二氢-1-甲基-4-氧代-1H-咪唑-2-基）脲；N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

Empirical Formula (Hill Notation): C11H11ClN4O2 CAS号: 57653-26-6 分子量: 266.68 MDL编号: MFCD00868019 PubChem化学物质编号: 24894721 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: F0430
CAS号: 57653-26-6
MDL号: MFCD00868019
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¥1,130.00

说明

生化/生理作用

Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
 

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

颜色

white

溶解性

DMSO: >20 mg/mL

创始人

Johnson & Johnson

储存温度

2-8°C

SMILES string

CN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2

InChI

1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)

InChI key

DWPQODZAOSWNHB-UHFFFAOYSA-N

 

安全信息

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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