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腐胺二盐酸盐,Putrescine dihydrochloride;powder, BioReagent, suitable for cell culture, ≥97% (TLC)

别名:1,4-丁二胺二盐酸盐;1,4-二氨基丁烷二盐酸盐; 四亚甲基二胺二盐酸盐;1,4-Butanediamine dihydrochloride;1,4-Diaminobutane dihydrochloride;Tetramethylenediamine dihydrochloride

CAS号 333-93-7 线性分子式 NH2(CH2)4NH2 · 2HCl 分子量 161.07 Beilstein/REAXYS Number 3906680 EINECS 编号 206-375-9 MDL number MFCD00012526 PubChem Substance ID 24898707 NACRES NA.75
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): P5780
CAS号: 333-93-7
MDL号: MFCD00012526
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¥334.07

产品描述

General description

Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour.[2] It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase.[7] Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.[5]

腐胺是死亡组织中脂肪酸代谢的最终产物。 它是一种具有刺激性气味的挥发性二胺。[2] 它是在鸟氨酸脱羧酶存在的情况下,通过鸟氨酸的脱羧作用合成的。[7] 分子对接研究揭示了腐胺与嗅觉上皮细胞中存在的称为痕量胺相关受体(TAAR6和TAAR8)的人类受体结合。[5]

Application

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture,[6] retinal ganglion cell culture[1] and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.[7]

盐酸腐胺被用作F-12 + GlutaMax培养基的成分,用于小鼠神经节培养,视网膜神经节细胞培养和HCT116结肠癌细胞中用于鸟氨酸脱羧酶(ODC)分析。

Biochem/physiol Actions

Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress.[3] It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants.[4] It serves as an attractant for predators.[6]

结合到 NMDA 受体的聚胺调控位点并增强 NMDA 感应电流;亚精胺的前体。

性质

Quality Level  200
biological source  microbial
 synthetic
product line  BioReagent
assay  ≥97% (TLC)
form  powder
application(s)  cell culture | mammalian: suitable
mp  280 °C (dec.) (lit.)
solubility  H2O: 100 mg/mL
SMILES string  Cl[H].Cl[H].NCCCCN
InChI  1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
InChI key  XXWCODXIQWIHQN-UHFFFAOYSA-N


安全信息

符号 
信号词 Danger
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xi
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26
RIDADR NONH for all modes of transport
WGK德国 WGK 1
RTECS EJ7280000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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