过滤
关闭导航

脱镁叶绿酸a,Pheophorbide-a;≥90% (HPLC)

别名:脱镁叶绿酸a5;脱乙酰基-2-乙烯基细菌脱镁叶绿素;pheophorbide a, Pheophorbide a5, (3S,4S,21R)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid, Deacetyl-2-vinylbacteriopheophorbide

Empirical Formula (Hill Notation): C35H36N4O5 CAS号: 15664-29-6 分子量: 592.68 MDL编号: MFCD00210345 PubChem化学物质编号: 329825726
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1218
CAS号: 15664-29-6
MDL号: MFCD00210345
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥2,660.00

说明

由于其光敏作用,脱镁叶绿素-a 可作为治疗利什曼病的有希望的生物活性化合物。 它是叶绿素的代谢产物,具有免疫刺激功能。 Pheophorbide-a 是一种用于光动力疗法的光敏剂。 它是一种 ATP 结合盒亚科 G 成员 2 (ABCG2) 转运蛋白特异性底物。 癌细胞中 ATP 结合盒 (ABC) 转运蛋白的过度表达与多药耐药表型有关。

应用

Pheophorbide-a has been used as a photosensitizer:
  • for the photodynamic therapy (PDT) in oral cancer cell lines
  • to test its effect on inducing oxidative stress and death in L. amazonensis
  • to test its effect on the viability of HeLa cells
 

生化/生理作用

Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.
 

其他说明

light sensitive
 
 

属性

测定

≥90% (HPLC)

形式

powder

储存条件

protect from light

颜色

blue, to dark brown to black

溶解性

DMSO: 0.5 mg/mL, clear (warmed)

储存温度

−20°C

SMILES string

O=C([C@@H]1C(OC)=O)C(C(N/2)=C1C([C@@H](CCC(O)=O)[C@@H]/3C)=NC3=C/4)=C(C)C2=C\C5=N/C(C(C)=C5CC)=C\C6=C(C=C)C(C)=C4N6

InChI

1S/C35H36N4O5/c1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/h8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/b22-12-,23-13-,24-12-,25-14-,26-13-,27-14-,32-30-/t17-,21-,31+/m0/s1

InChI key

NSFSLUUZQIAOOX-QEWKCGBTSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32