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脱氢枞酸 [脱氢松香酸],Dehydroabietic acid [DHA, DAA];≥95% (LC/MS-ELSD)

别名:脱氢碳酸酯;松香酸-8,11,13-三烯-18-酸;Abieta-8,11,13-trien-18-oic acid, Dehydroabietate

Empirical Formula (Hill Notation): C20H28O2 CAS号: 1740-19-8 分子量: 300.44 EC 号: 217-102-8 MDL编号: MFCD09839012 PubChem化学物质编号: 329824767 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SMB00089
CAS号: 1740-19-8
MDL号: MFCD09839012
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说明

脱氢枞酸(DHA)具有多种生物活性,如抗癌、抗衰老、抗菌、抗溃疡、保护胃和细胞毒活性。 它是一种有效的抗炎剂和过氧化物酶体增殖物激活受体 α 和 γ (PPAR α/γ) 的双重激活剂。 DHA 具有抗衰老作用和 Sirtuin 1 (SIRT1) 激活化合物。 它对多重耐药菌株具有抗菌特性。 脱氢松香酸及其衍生物具有胃保护和细胞毒作用。

一般描述

脱氢枞酸(DHA 或 DAA)是一种具有生物活性的双萜类植物化学物质,存在于各种松属物种中。它是树脂酸和松香酸(AA)的衍生物。
 

应用

Dehydroabietic acid has been used as a reference standard:
  • to study the aging process of Pinus resins using Fourier-transform infrared spectroscopy (FTIR)
  • to study the composition changes in Pinus genus with aging using Raman spectroscopy complemented with infrared spectroscopy
  • to estimate resistance against biotic stress as proxy in chemical defenses in Pinus halepensis

生化/生理作用

Dehydroabietic acid (DHA) exerts various biological activities such as anti-cancer, anti-aging, antimicrobial, antiulcer, gastroprotective, and cytotoxic activities. It is a potent anti-inflammatory agent and a dual activator of peroxisome proliferator-activated receptors alpha and gamma (PPAR α/γ). DHA has an anti-aging effect and a sirtuin 1 (SIRT1) activating compound. It has antibacterial properties against multidrug-resistant strains. dehydroabietic acid and its derivatives have gastroprotective and cytotoxic effects.
 
 

属性

测定

≥95% (LC/MS-ELSD)

形式

solid

储存温度

−20°C

SMILES string

CC(C)c1ccc2c(CC[C@H]3[C@@](C)(CCC[C@]23C)C(O)=O)c1

InChI

1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1

InChI key

NFWKVWVWBFBAOV-MISYRCLQSA-N

 

安全信息

象形图

Skull and crossbonesEnvironment

警示用语:

Danger

危险声明

预防措施声明

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10