脂蛋白脂酶来源于伯克霍尔德氏菌,Lipoprotein Lipase from Burkholderia sp.;lyophilized powder, ≥50,000 units/mg solid

别名:脂蛋白脂肪酶;二酰基甘油脂(肪)酶;甘油二酯酰水解酶;Diacylglycerol acylhydrolase;Diacylglycerol lipase;Lipoprotein Lipase from Pseudomonas sp.

CAS号 9004-02-8 Enzyme Commission (EC) Number ( BRENDA | IUBMB ) EINECS 编号 232-669-1 MDL number MFCD00131523 NACRES NA.54
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): L9656
CAS号: 9004-02-8
MDL号: MFCD00131523
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General description

Lipoprotein Lipase (LPL) is a glycerol ester hydrolase. Several bacteria that produce LPL, belongs to the genus Pseudomonas, Serratia and Mucor.[7]

Lipoprotein lipase hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. [4]


Lipoprotein Lipase from Burkholderia sp. has been used in the subcellular fractionation of mussel Mytilus galloprovincialis to identify the biomolecule attached to cytosolic fraction of okodaic acid.[5] It has also been used to test its effect on serum amyloid A induced granulocyte colony-stimulated factor (G-CSF) expression in response to bacterial lipoprotein.[6]

Lipoprotein lipase has been used in a study to assess the role of lipogenic enzymes in colorectal cancer. [2] It has also been used in a study to investigate lipasemic activity of low molecular weight heparin in rats. [3]


10 mg in glass bottle

50 mg in poly bottle

Biochem/physiol Actions

Due to its lipolytic activity, lipoprotein lipase was shown to effectively block the spread of hepatitis C virus into healthy cells. [1]

Lipoprotein Lipase (LPL) hydrolysis triacylglycerol moieties in chylomicron and low density lipoproteins.[7][8] LPL attaches lipoprotein to the vessel wall and facilitates their uptake.[8] Abnormalities in LPL is associated with Alzheimer′s disease, atherosclerosis, obesity and chylomicronaemia.[9]

Lipoprotein lipase belongs to the family of triglyceride lipases. It hydrolyses triglycerides in triglyceride-rich ApoB-containing lipoproteins.

Unit Definition

One unit will release 1.0 nmole of p-nitrophenol per min at pH 7.2 at 37 °C using p-nitrophenyl butyrate as substrate.


Quality Level200
formlyophilized powder
specific activity≥50,000 units/mg solid
storage temp.−20°C


个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62