胆钙化醇 [维生素D3]，Cholecalciferol；meets USP testing specifications, 97.0-103.0%

General description

Cholecalciferol (vitamin D3), a fat-soluble steroid is produced in the skin.^[1]

Application

Cholecalciferol has been used:
• to induce arterial medial calcification (AMC) in mice^[2]
• to study its impact in vascular remodeling associated with vascular calcification (VC) in murine model of obesity and insulin resistance (ob/ob mice)^[3]
• to study its effect on anchorage dependent growth of RWPE2-W99 cells in monolayer culture^[4]

包装

1 g in ampule

25 g in glass bottle

250 mg in ampule

Biochem/physiol Actions

维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。

性质

安全信息

符号

  GHS06,GHS08

信号词 Danger

危害声明 H301 + H311 - H330 - H372

警示性声明 P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314

个人防护装备 Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

危害码 (欧洲) T+

风险声明 (欧洲) 24/25-26-48/25

安全声明 (欧洲) 28-36/37-45

RIDADR UN 2811 6.1 / PGII

WGK德国 WGK 2

RTECS VS2900000