General description
Cholate is a primary bile acid[3] produced from cholesterol in the liver.[5] It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1).[1]
Application
Sodium cholate hydrate has been used:
• as a bile acid to induce bile acid-responsive (BEAR) transcription system[2],
• as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52
• to test its sensitivity towards the bile acid sensor[4]
用于提取膜蛋白的非变性洗涤剂。
包装
25, 100 g in poly bottle
Biochem/physiol Actions
Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease.[5]