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胆固醇,Cholesterol;tested according to Ph Eur [药典级]

别名:药典级胆固醇;胆甾-5-烯-3β-醇,胆甾醇,3β-Hydroxy-5-cholestene,5-Cholesten-3β-ol

CAS号 57-88-5 经验分子式(希尔表示法) C27H46O 分子量 386.65 Beilstein/REAXYS Number 1915888 EINECS 编号 200-353-2 MDL number MFCD00003646 PubChem Substance ID 329750548 NACRES NA.21
货号(SKU): 14606
CAS号: 57-88-5
MDL号: MFCD00003646
增值税发票 √ 免费货运 [顺丰 联邦] √
$259.45

产品描述

胆固醇用于制备含卵白蛋白(OVA)的ISCOMS,用于研究在亲脂性免疫刺激复合物(ISCOMS)中掺入蛋白抗原卵白蛋白(OVA)是否诱导非常强的初次免疫反应。 它被掺入动物饲料中以研究富含胆固醇的饮食的效果。胆固醇是一种脂质,占细胞膜结构成分的约20-25%。 它决定了膜的流动性和渗透性,使其对水可渗透,但对离子和质子不渗透。 胆固醇还调节质膜上存在的转运蛋白和信号蛋白的功能。胆固醇合成的主要部位是小肠和肝脏。

Application

Cholesterol was used for preparing ISCOMS containing ovalbumin (OVA) for studying whether the incorporation of the protein antigen ovalbumin (OVA) in lipophilic immune-stimulating complexes (ISCOMS) induces very strong primary immune responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.[4][3]

Biochem/physiol Actions

Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane.[1] The major sites of cholesterol synthesis are small intestine and liver.[2]

所有生物膜的主要成分;总脑脂质中含 ~25% 的胆固醇。

性质

Agency/Methodtested according to Ph Eur
Quality Level100
formpowder
bp360 °C (lit.)
mp147-149 °C (lit.)
solubilitychloroform: soluble 1 gm in 4.5 ml
diethyl ether: soluble 1 gm in 2.8 ml
pyridine: soluble 1 gm in 1.5 ml
H2O: insoluble
acetone: soluble
alcohol: slightly soluble
alcohol: very soluble (Hot)
benzene: soluble
dioxane: soluble
ethyl acetate: soluble
hexane: soluble
oil: soluble
petroleum ether: soluble
density1.067 g/mL at 25 °C (lit.)
Featured IndustryPharmaceutical (small molecule)
storage temp.2-8°C
SMILES stringCC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI keyHVYWMOMLDIMFJA-DPAQBDIFSA-N
Gene Informationhuman ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 1
RTECS FZ8400000
闪点(华氏) Not applicable
闪点(摄氏) Not applicable
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62
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