聚乙二醇(15)-羟基硬脂酸酯，Kolliphor HS 15 [Solutol HS 15]

别名：巴斯夫BASF Solutol® HS 15；BASF 非离子型去污剂；聚乙二醇（15）-羟基硬脂酸酯；聚氧乙烯化的12-羟基硬脂酸；Macrogol (15)-hydroxystearate, Polyethylene glycol (15)-hydroxystearate, Polyoxyethylated 12-hydroxystearic acid

CAS号: 70142-34-6 PubChem化学物质编号: 329756293

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: 42966

CAS号: 70142-34-6

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目录规格.SKU-Variant

说明

一般描述

Kolliphor^® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

应用

Kolliphor^® HS 15 has been used:

in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force
in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses
to dissolve finerenone for oral application in in vivo-studies

生化/生理作用

Kolliphor^® HS 15 is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. Kolliphor^® HS 15 is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. Kolliphor^® HS 15 can be used to develop micro-emulsion IV formulations.

特点和优势

Low histamine release for fewer side-effects
Offers thermal stability, suitable for heat sterilization
Has lower hemolytic activity than other polyoxyethylene-based surfactants
Allows to formulate poorly soluble APIs in oral and parenteral dosage forms

其他说明

Kolliphor HS 15是一种通过使15摩尔环氧乙烷与1摩尔12-羟基硬脂酸反应得到的非离子型去污剂。

This research-grade product is intended for use in R&D and development only.

法律信息

Kolliphor is a registered trademark of BASF

Solutol is a registered trademark of BASF SE

属性

描述

non-ionic

质量水平

100

组成

free macrogoly% (27.0 - 39.0 g/100g (%))

杂质

acetic acid (≤ 0.5 g/100g (%))
water (≤ 0.5 g/100g (%))
≤1 mg/kg ethylene oxide ((ppm))
≤1 mg/kg nickel ((ppm))
≤10 mg/kg dioxane ((ppm))
≤620 mg/kg diethylene glycol ((ppm))
≤620 mg/kg ethylene glycol ((ppm))
<10 mg/kg heavy metals ((ppm))

灼烧残渣

(≤ 0.3 g/100g (%))

pH值（酸碱度）

5.0-7.0 (1 g/10 mL in H₂O)

酸值

≤1.0 mg KOH/g

羟基值

90‑110 mg KOH/g

碘值

≤2.0 g I₂/100 g

过氧化值

≤3.0 meq/kg

皂化值

53‑63 mg KOH/g

application(s)

sample preservation

SMILES string

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCCCCCC(O)CCCCCCCCCC(O)=O

InChI

1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)

InChI key

CYAMZYIUAHNTBO-UHFFFAOYSA-N

安全信息

象形图

GHS07

警示用语：

Warning

危险声明

H317

预防措施声明

P280

危险分类

Skin Sens. 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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