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美洛昔康钠盐水合物,Meloxicam sodium salt hydrate;≥98% (HPLC)

别名:4-羟基-2-甲基-N-(5-甲基-2-噻唑基)-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化钠水合物;美达康钠盐水合物;Mobec钠盐水合物;UH-AC 62XX钠盐水合物;4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate, Metacam sodium salt hydrate, Mobec sodium salt hydrate, UH-AC 62XX sodium salt hydrate

Empirical Formula (Hill Notation): C14H12N3NaO4S2 · xH2O CAS号: 71125-39-8 分子量: 373.38 (anhydrous basis) MDL编号: MFCD11046047 PubChem化学物质编号: 24278802 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): M3935
CAS号: 71125-39-8
MDL号: MFCD11046047
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说明

美洛昔康是 oxicam 家族的一员,是一种非甾体抗炎药 (NSAID)。 它是由具有芳基和吡啶环取代的吡罗昔康合成的。 美洛昔康是一种环氧合酶 2 (COX-2) 抑制剂,可用于治疗炎症和疼痛。 已显示美洛昔康可阻止大鼠肝脏中胸腺素诱导的细胞因子和神经生长因子 (NGF) 浓度增加。 美洛昔康还抑制肿瘤生长,并且可能能够在体外拮抗恶病质。 它促进肝细胞癌的细胞凋亡。

应用

Meloxicam sodium salt hydrate has been used:
  • as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
  • as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
  • as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
  • to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells

生化/生理作用

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro. It promotes apoptosis in hepatocellular carcinoma.
 

特点和优势

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

light yellow to dark yellow

溶解性

DMSO: 5 mg/mL, clear

创始人

Boehringer Ingelheim

储存温度

room temp

SMILES string

O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O

InChI

1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1

InChI key

IZBZAOZGNNQKPJ-UHFFFAOYSA-M

Gene Information

human ... PTGS2(5743)

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
商品标签 [tags]