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罗丹明123,Rhodamine 123;BioReagent, for fluorescence, ≥85% (HPLC)

别名:线粒体特异性荧光染料;玫瑰红123;2-(6-氨基-3-亚氨基-3H-呫吨-9-基)苯甲酸甲酯;2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester

CAS号 62669-70-9 线性分子式 C21H17ClN2O3 分子量 380.82 Beilstein/REAXYS Number 6030951 EINECS 编号 263-687-8 MDL number MFCD00012664 PubChem Substance ID 57652966 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 83702
CAS号: 62669-70-9
MDL号: MFCD00012664
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¥8,405

产品描述

General description

Rhodamine 123 is a fluorescent dye.[3]

Application

Rhodamine 123 has been used:
• as a substrate for P-glycoprotein (P-gp) to read out functional transporter activity in fluorescent accumulation assays[2]
• to label the cells for estimating the P-gp expression by flow cytometry[3]
• in transport studies, was added to the apical to basolateral (AB-transport) or basolateral to apical (BA-transport)[4]
• the detection of mitochondrial membrane potential (ΔΨm)[5]

Biochem/physiol Actions

Rhodamine 123 is usually used as a functional reporter for P-glycoprotein (P-gp) in flow cytometry.[3]

最常用于流式细胞术的荧光染料,可用作Pgp的功能性报告分子。在癌症治疗中,MDR蛋白的功能测定是比MDR蛋白表达水平更好的预后指标。Rh 123可用于多参数分析而无荧光干扰,可与常用蛋白质标记染料组合使用,如PE-Cy5和AMCA(7-氨基-4-甲基香豆素-3-乙酸)。近期报道表明,Rh123也可能是MRP1的底物。

Other Notes

上活体线粒体特异性染料[1]

性质

Quality Level100
gradefor fluorescence
product lineBioReagent
assay≥85% (HPLC)
impurities≤10% water
solubilityethanol: 20 mg/mL, clear, red
suitabilityin accordance for fluorescence
SMILES stringCl[H].COC(=O)c1ccccc1C2=C3C=CC(=N)C=C3Oc4cc(N)ccc24
InChI1S/C21H16N2O3.ClH/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20;/h2-11,22H,23H2,1H3;1H
InChI keyMYFATKRONKHHQL-UHFFFAOYSA-N


安全信息

RIDADR NONH for all modes of transport
WGK德国 3
RTECS ZE0883000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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