缬氨霉素，Valinomycin；≥98% (TLC), ≥90% (HPLC)

图片 缬氨霉素，Valinomycin；≥98% (TLC), ≥90% (HPLC)
别名：缬氨菌素；钾离子载体 I；Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

Empirical Formula (Hill Notation): C54H90N6O18 CAS号: 2001-95-8 分子量: 1111.32 Beilstein: 78657 EC 号: 217-896-6 MDL编号: MFCD00005114 PubChem化学物质编号: 24900697 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: V0627
CAS号: 2001-95-8
MDL号: MFCD00005114
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说明

一般描述

化学结构：肽
Valinomycin is a cyclic peptide, which contains d-valine, d-α-hydroxyvaleric acid, l-valine, and l-lactic acid in the sequential order of cyclo-[(l-Val-d-Hyv-d-Val-l-Lac)3].
 

应用

Valinomycin has been used:
  • to equilibrate intracellular pH and extracellular pH of 5 (and 6-)-carboxyfluorescein succinimidyl ester (cFSE) in Escherichia coli strain B23
  • as an ionophore to equilibrate intracellular pH and extracellular pH of lactic acid bacteria (LAB) strains
  • to establish the desired pH for acid-base transition and formation of K+-valinomycin diffusion potential

生化/生理作用

K+选择性离子载体环羧酚酸肽；钾离子载体，其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。
Valinomycin selectively transfers alkali metal ions via biological and synthetic membranes. The formation of a metal ion-peptide complex contributes to this ion-transporting. Valinomycin can create stable complexes with potassium, rubidium, and cesium (K+, Rb+, and Cs+) .
 

其他说明

保存于密闭容器内，置于干燥通风处。
 
 

属性

质量水平

300

测定

≥90% (HPLC)
≥98% (TLC)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white

溶解性

DMSO: ≥50 mg/mL
H2O: insoluble

抗生素抗菌谱

Gram-positive bacteria
parasites
viruses

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES string

CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

InChI

1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1

InChI key

FCFNRCROJUBPLU-RPUZOQEISA-N

 

安全信息

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H310

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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