维生素B12 [氰钴胺素, 腈钴胺]，Vitamin B12 [CN-Cbl, VB12]；tested according to Ph. Eur., 96.0-102.0% dry basis

别名：氰基钴胺素；氰钴胺；氰可可碱(III)阿拉明；α-(5,6-二甲基苯并咪唑基)氰基钴酰胺；动物蛋白因子；抗恶性贫血维生素；维生素乙B12；维他命B12；CN-Cbl；α-(5,6-Dimethylbenzimidazolyl)cyanocobamide；Cyanocob(III)alamin；Cyanocobalamin

Empirical Formula (Hill Notation): C63H88CoN14O14P CAS号: 68-19-9 分子量: 1355.37 Beilstein: 4122889 EC 号: 200-680-0 PubChem化学物质编号: 329756307 NACRES: NA.21

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: 43107

CAS号: 68-19-9

MDL号: MFCD00151092

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录规格.SKU-Variant

10g
100g

说明

氰钴胺，也称为维生素B12，是一种水溶性维生素。
在ELISA的分析步骤期间，在测定缓冲液中加入氰钴胺素，以确保在分析之前所有的转钴胺素都被钴胺素饱和。氰基巴胺还用于检查其对体内mPer1和mPer2表达的影响。

氰胺在大脑和神经系统的功能中发挥作用。它也参与造血。维生素B12缺乏导致巨幼细胞性贫血。它还与导致脊髓退化的不可逆神经系统崩溃有关。
氰钴胺是指一组化学相关的含钴分子，参与细胞过程，如DNA合成、脂肪酸合成、能量生产和调节。氰钴胺素与其他B族维生素硫胺素（B1）和吡哆醇（B6）一起阻断脊髓神经节压迫（CCD）或坐骨神经松脱结扎（CCI）引起的神经性疼痛大鼠的热痛觉过敏。它能促进氯仿的厌氧生物降解。

一般描述

Cyanocobalamin, also referred to as Vitamin B₁₂, is a water soluble vitamin.

应用

Cyanocobalamin was added in the assay buffer during the analysis step of ELISA for ensuring that all transcobalamin was saturated with cobalamin before analysis. Cyanocobalamin was also used for examining its impact on the expression of mPer1 and mPer2 in vivo.

生化/生理作用

Cyanocobalamin plays a role in functioning of brain and nervous system. It is also involved in hematopoiesis. Vitamin B₁₂ deficiency leads to megaloblastic anemia. It is also associated with irreversible nervous system breakdown leading to spinal cord degeneration.

Cyanocobalamin refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. Cyanocobalamin along with other B vitamins thiamine (B1) and pyridoxine (B6) blocks the thermal hyperalgesia in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ligation of the sciatic nerve (CCI). It can stimulate the anaerobic biodegradation of chloroform.

属性

生物来源

fermentation/recombinant

质量水平

100

Agency

USP/NF
tested according to Ph. Eur.

测定

96.0-102.0% dry basis

形式

powder

颜色

dark red

溶解性

water: soluble 1 gm in 80 ml
acetone: insoluble
alcohol: soluble
chloroform: insoluble
diethyl ether: insoluble

application(s)

cell analysis

储存温度

2-8°C

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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