Application
Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.
包装
1 g in poly bottle
10, 50, 100, 250 mg in poly bottle
Biochem/physiol Actions
细胞色素c可在亚铁态和三价铁态之间迅速转化,这使其成为有效的生物电子载体。它在动植物的细胞氧化过程中发挥重要作用。通常视作是呼吸链中的通用连接,它在可呼吸底物与氧气之间形成必要的电子桥。Preparation Note
Prepared with acetic acid without using TCA.
Other Notes
想要了解更多细胞色素c和电子传递的信息,请访问www.sigma-aldrich.com/enzymeexplorer.